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Microbes and Health

Organized by Jeffrey Gordon and Todd Klaenhammer, this meeting was held at the Beckman Center in Irvine, CA on November 2-3, 2009.  This colloquium focused on characterization of the foundations of host-microbial symbioses, primarily in the human.   Given the remarkable growth of the field of metagenomics, and the astonishing proliferation of human microbiome initiatives in many nations, it was timely to convene a colloquium that examined the assembly, composition, functions and dynamic operations of body habitat-associated microbial communities.  The microbiota plays many important roles in maintaining health and in promoting various diseases and this colloquium discussed the experimental and computational approaches that are being, and need to be, deployed to comprehensively characterize our microbiome in health and disease, and interventional strategies that may be useful for its deliberate manipulation.

This meeting was co-sponsored by the International Scientific Association for Probiotics and Prebiotics (ISAPP) and was followed by their Annual meeting on November 4-5. 

A Special Feature of PNAS was published in March 2011.  You can read the collection of colloquuim papers online here.

Click on the title to view the recording or click on the ipod icon to download to your mobile device.

Monday, November 2, 2009

Opening Addresses
Session Chair:  Jeffrey Gordon, Washington University School of Medicine

Play on iPhone, iPod, or download to iTunes Nancy Moran, University of Arizona, Evolution of biological complexity and symbiosis

Session I:  Setting the Stage

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Rob Knight, University of Colorado, Boulder, The 16S rRNA renaissance: computational and experimental perspectives

Play on iPhone, iPod, or download to iTunes Jonathan A. Eisen, University of California, Davis, Looking at the tree of life
  
Play on iPhone, iPod, or download to iTunes Elaine Holmes, Imperial College London, An integrated systems biology view of host microbial interactions  
 

Play on iPhone, iPod, or download to iTunes Elaine Vaughan, Unilever Research & Development, Approaches to study bioconversion of dietary polyphenols by gut  microbiota 
                                        

Play on iPhone, iPod, or download to iTunes Bart Keijser, TNO, Exploring the oral microbial diversity using the OC chip 
                                                                                                                                                                                                                                                                                                                                                            

 

Play on iPhone, iPod, or download to iTunes Joel Dore, INRA, Metagenomic studies of the human gut 

 

Play on iPhone, iPod, or download to iTunes Forest Rohwer, San Diego State University, Viral diversity in human and non-human habitats   

 

Play on iPhone, iPod, or download to iTunes David Relman, Stanford University, Antibiotics: a tool to probe ecosystem robustness and diversity        
                                  
                           

Session II:  Case studies

Play on iPhone, iPod, or download to iTunes Michiel Kleerebezem, Wageningen University, Monitoring transcriptional responses in the human gut to the microbiota

 

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Karen Guillemin, University of Oregon, Using gnotobiotic zebrafish to dissect the foundations of host-microbial interactions 


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Ruth Ley, Cornell University, A deeper look into maternal programming of the infant gut microbiota

 

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Paul O'Toole, University College Cork, Gut microbiota of the elderly - The ELDERMET Consortium

                               Fredrik Backhed, University of Gothenburg, Tissue factor promotes microbiota-induced angiogenesis in the gut

 

Tuesday, November 3, 2009

Session III: Interactions between microbial communities and the immune system

 

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Jerry Wells, Wageningen University, Intestinal homeostasis and the role of innate recognition of microbes at the epithelial surface

Play on iPhone, iPod, or download to iTunes Sarkis Mazmanian, California Institute of Technology, Innate immune responses to commensal bacteria
 

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 Wendy Garrett, Harvard University, Lessons about the interplay between the immune system and the microbiota

   

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Ramnik Xavier, Harvard University, A systems biology view of host-microbial interactions in IBD

 

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Colin Hill, University College Cork, Antimicrobials and potential modification of microbiota

                                Jens Walter, University of Nebraska, Evolution of the gut symbiont Lactobacillus reuteri

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Alan Huett, Massachusetts General Hospital, An automated screen of secreted bacterial effector proteins to identify modulators of mammalian autophogy
 

Session IV:  Glycobiology redux
 

Play on iPhone, iPod, or download to iTunes David Mills, University of California, Davis, The human glycobiome and its impact on the infant microbiota

  
Play on iPhone, iPod, or download to iTunes Gunnar C. Hansson, University of Gothenburg, Mucus - a legislator of host-microbial interactions
 

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Dennis Kasper, Harvard University, Cell surface glycans as therapeutic agents
                                                                     

 Session V:  Manipulations of the microbiota

Play on iPhone, iPod, or download to iTunes Karen Scott, University of Aberdeen, Impact of dietary manipulations on human microbial ecology and health

Play on iPhone, iPod, or download to iTunes Larry Forney, University of Idaho, The vagina microbiome and microbiota
   

Play on iPhone, iPod, or download to iTunes  Gregor Reid, University of Western Ontario, Clinical manifestations of the vaginal microbiota in health or disease
 

Closing address   Todd Klaenhammer and Jeffrey Gordon, Closing comments and moving forward